Prolonged measles virus shedding in human immunodeficiency virus-infected children, detected by reverse transcriptase-polymerase chain reaction. Academic Article uri icon

Overview

abstract

  • A reverse transcriptase-polymerase chain reaction assay was used to detect measles virus RNA in peripheral blood mononuclear cells, urine, and nasopharyngeal specimens from Zambian children during hospitalization and approximately 1-2 months after discharge. Of 47 children, 29 (61.7%) had prolonged measles virus shedding, as defined by detection of measles virus RNA in > or =1 specimen obtained 30-61 days after rash onset. Ten (90.9%) of 11 human immunodeficiency virus (HIV)-infected children had prolonged measles virus shedding, compared with 19 (52.8%) of 36 HIV-uninfected children (P=.02). Prolonged measles virus shedding did not correlate with levels of measles virus-specific antibody. HIV-infected children with measles may have a prolonged infectious period that potentially enhances measles virus transmission and hinders measles control.

publication date

  • January 18, 2001

Research

keywords

  • HIV Infections
  • Measles
  • Measles virus
  • Virus Shedding

Identity

Scopus Document Identifier

  • 0035865850

Digital Object Identifier (DOI)

  • 10.1086/318533

PubMed ID

  • 11170977

Additional Document Info

volume

  • 183

issue

  • 4