Impaired regeneration of the peripheral B cell repertoire from bone marrow following lymphopenia in old mice. Academic Article uri icon

Overview

abstract

  • Aging is associated with a decreased production of B cells by the bone marrow and an increased life-span of peripheral B cells. To determine whether the decreased bone marrow B cell production is linked to the increased life-span of B cells in old mice, B cell regeneration following lymphopenia was studied in young and old mice. The rate of bone marrow pre-B cell and of splenic B cell regeneration is slower in irradiated, old compared to irradiated, young recipients of young, congeneic bone marrow. This finding reflects an age-associated defect in the bone marrow microenvironment. As the bone marrow is the only source of a diverse population of B cells, we measured the diversity of the splenic B cell repertoire regenerated following drug-induced lymphopenia in old and young mice. The heterogeneity of mRNA size from IgH complementarity determining region 3 (CDR3) was more restricted in splenic B cells from old compared to young mice providing additional evidence for an age-associated impairment in B cell production by the bone marrow.

publication date

  • February 1, 2001

Research

keywords

  • Aging
  • B-Lymphocytes
  • Bone Marrow Cells
  • Regeneration

Identity

Scopus Document Identifier

  • 0035104210

Digital Object Identifier (DOI)

  • 10.1002/1521-4141(200102)31:2<500::aid-immu500>3.0.co;2-c

PubMed ID

  • 11180115

Additional Document Info

volume

  • 31

issue

  • 2