Nerve entrapment syndromes can occur in athletes. The repetitive and vigorous use or overuse of the upper extremity makes the athlete particularly vulnerable to disorders of peripheral nerves. Understanding the clinical signs and symptoms is essential to treatment. The pertinent anatomy, clinical presentation, treatment, and rehabilitation necessary for return to sports for various nerve entrapments have been described. This should enable the physician caring for the athlete to help prevent injury and to guide appropriate treatment, if intervention becomes necessary.