cis-hydroxyproline limits work necessary to flex a digit after tendon injury. Academic Article uri icon

Overview

abstract

  • Present surgical procedures for the repair of tendon injury are complicated by formation of peritendinous collagenous adhesions which restrict tendon gliding. Several sensitive biomechanical tests have been developed to quantitate peritendinous restriction of gliding. Using these tests it was found that cis-hydroxyproline significantly limits net collagen accumulation following tendon injury in a rat model and decreases the adhesive restraints to tendon gliding. cis-Hydroxyproline and other proline analoques offer a method for specifically preventing excessive collagen formation.

publication date

  • January 1, 1975

Research

keywords

  • Cicatrix
  • Disease Models, Animal
  • Hydroxyproline
  • Physical Exertion
  • Tendon Injuries

Identity

Scopus Document Identifier

  • 0016693041

Digital Object Identifier (DOI)

  • 10.1097/00003086-197506000-00028

PubMed ID

  • 1132201

Additional Document Info

issue

  • 109