A coordinated change in chemokine responsiveness guides plasma cell movements. Academic Article uri icon

Overview

abstract

  • Antibody-secreting plasma cells are nonrecirculatory and lodge in splenic red pulp, lymph node medullary cords, and bone marrow. The factors that regulate plasma cell localization are poorly defined. Here we demonstrate that, compared with their B cell precursors, plasma cells exhibit increased chemotactic sensitivity to the CXCR4 ligand CXCL12. At the same time, they downregulate CXCR5 and CCR7 and have reduced responsiveness to the B and T zone chemokines CXCL13, CCL19, and CCL21. We demonstrate that CXCL12 is expressed within splenic red pulp and lymph node medullary cords as well as in bone marrow. In chimeric mice reconstituted with CXCR4-deficient fetal liver cells, plasma cells are mislocalized in the spleen, found in elevated numbers in blood, and fail to accumulate normally in the bone marrow. Our findings indicate that as B cells differentiate into plasma cells they undergo a coordinated change in chemokine responsiveness that regulates their movements in secondary lymphoid organs and promotes lodgment within the bone marrow.

publication date

  • July 2, 2001

Research

keywords

  • Chemokines
  • Chemokines, CXC
  • Plasma
  • Receptors, CXCR4

Identity

PubMed Central ID

  • PMC2193440

Scopus Document Identifier

  • 0035796411

Digital Object Identifier (DOI)

  • 10.1084/jem.194.1.45

PubMed ID

  • 11435471

Additional Document Info

volume

  • 194

issue

  • 1