Whole-brain blood flow and oxygen metabolism in the rat during nitrous oxide anesthesia. Academic Article uri icon

Overview

abstract

  • The Kety-Schmidt washout technique has been modified to measure whole-brain blood flow and metabolism in the rat. During nitrous oxide anesthesia, 14 rats exhaled (133)Xe, and continuous and simultaneous arterial and cerebral venous samples were drawn from a femoral artery and the transverse sinus of the brain. Extracerebral contamination of the venous sample was minimal, and equilibration of (133)Xe in brain tissue and blood was obtained after 10-24 min of inhalation. Cerebral blood flow was calculated from the total activity of the mechanically integrated arterial and venous samples according to the principle of Scheinberg and Stead. At a mean Paco2 of 40 mmHg, CBF averaged 98 +/- 6 (SEM) ml/100 g-min and CMRO2 averaged 5.4 +/- 0.7 (SEM) ml/100 g-min. CBF changed 2.4% with each millimeter Hg change of Paco2 while CMRO2 changed only insignificantly. The values obtained for CBF are higher than reported for man and large laboratory animals bur reflect the proportionately greater amount of gray matter in the rat brain.

publication date

  • July 1, 1975

Research

keywords

  • Anesthesia, Inhalation
  • Brain
  • Cerebrovascular Circulation
  • Nitrous Oxide
  • Oxygen Consumption

Identity

Scopus Document Identifier

  • 0016773449

Digital Object Identifier (DOI)

  • 10.1152/ajplegacy.1975.229.1.113

PubMed ID

  • 1147036

Additional Document Info

volume

  • 229

issue

  • 1