Development of spontaneous factor VIII inhibitor in association with acute graft-versus-host disease. uri icon

Overview

abstract

  • A 57-year-old female with recurrent AML underwent a T cell-depleted (TCD) bone marrow (BM) plus TCD and CD34-selected peripheral blood stem cell (PBSC) transplant. Eleven weeks post transplantation, the patient developed acute graft-versus-host disease (GVHD) manifested by rash and elevated liver enzymes. Concurrently, the patient presented with a bleeding diathesis and a left forearm hematoma due to the development of a spontaneous factor VIII inhibitor. She was treated with human recombinant factor VIII and intravenous methylprednisolone. Subsequently she was managed with a prednisone taper leading to resolution of the GVHD, as well as the spontaneous factor VIII inhibitor. Bone marrow transplant-related spontaneous factor VIII inhibitor has previously been reported in association with one patient with chronic GVHD. To our knowledge this is the first report of spontaneous factor VIII inhibitor associated with acute GVHD.

publication date

  • April 1, 2001

Research

keywords

  • Factor VIII
  • Graft vs Host Disease
  • Isoantibodies

Identity

Scopus Document Identifier

  • 0034992797

Digital Object Identifier (DOI)

  • 10.1038/sj.bmt.1703009

PubMed ID

  • 11477449

Additional Document Info

volume

  • 27

issue

  • 8