Using positron emission tomography with [(18)F]FDG to predict tumor behavior in experimental colorectal cancer. Academic Article uri icon

Overview

abstract

  • This study investigates the relationship between FDG uptake as determined by positron emission tomography (PET) imaging and rates of tumor growth, cellular GLUT1 transporter density, and the activities of hexokinase and glucose-6-phosphatase in a solid tumor implant model. Five different human colorectal xenografts of different growth properties were implanted in athymic rats and evaluated by dynamic (18)F-FDG-PET. The phosphorylating and dephosphorylating activities of the key glycolytic enzymes, hexokinase and glucose-6-phosphatase, were measured in these tumor types by spectrophotometric assays and the expression of GLUT1 glucose transporter protein was determined by immunohistochemistry. Correlations among FDG accumulation, hexokinase activity, and tumor doubling time are reported in these colon xenografts. The results indicate that the activity of tumor hexokinase may be a marker of tumor growth rate that can be determined by (18)F-FDG-PET imaging. PET scanning may not only be a useful tool for staging patients for extent of disease, but may provide important prognostic information concerning the proliferative rates of malignancies.

publication date

  • January 1, 2001

Research

keywords

  • Colorectal Neoplasms
  • Fluorodeoxyglucose F18
  • Tomography, Emission-Computed

Identity

PubMed Central ID

  • PMC1505592

Scopus Document Identifier

  • 0034885978

Digital Object Identifier (DOI)

  • 10.1038/sj.neo.7900147

PubMed ID

  • 11494112

Additional Document Info

volume

  • 3

issue

  • 3