Genetic differences between adenocarcinomas arising in Barrett's esophagus and gastric mucosa. Academic Article uri icon

Overview

abstract

  • BACKGROUND & AIMS: Barrett adenocarcinoma (BA+) and gastric adenocarcinoma comprise a related group of neoplasms that nevertheless have some distinct clinicopathologic characteristics. This study aimed at defining critical molecular abnormalities that may underlie differences between BA+ and gastric adenocarcinomas. METHODS: We used comparative genomic hybridization for the analyses of 34 xenografts of adenocarcinomas that arose from esophageal or gastric origin. RESULTS: All tumors, except one, exhibited DNA copy number alterations. Losses in 4q and 14q and gains at 2p and 17q were more frequent in proximal (esophageal, gastroesophageal junction [GEJ], and cardia) tumors than in distal (body and antrum) tumors (P

publication date

  • September 1, 2001

Research

keywords

  • Adenocarcinoma
  • Barrett Esophagus
  • Esophageal Neoplasms
  • Stomach Neoplasms

Identity

Scopus Document Identifier

  • 0034837434

Digital Object Identifier (DOI)

  • 10.1053/gast.2001.27215

PubMed ID

  • 11522743

Additional Document Info

volume

  • 121

issue

  • 3