An effective AIDS vaccine based on live attenuated vesicular stomatitis virus recombinants. Academic Article uri icon

Overview

abstract

  • We developed an AIDS vaccine based on attenuated VSV vectors expressing env and gag genes and tested it in rhesus monkeys. Boosting was accomplished using vectors with glycoproteins from different VSV serotypes. Animals were challenged with a pathogenic AIDS virus (SHIV89.6P). Control monkeys showed a severe loss of CD4+ T cells and high viral loads, and 7/8 progressed to AIDS with an average time of 148 days. All seven vaccinees were initially infected with SHIV89.6P but have remained healthy for up to 14 months after challenge with low or undetectable viral loads. Protection from AIDS was highly significant (p = 0.001). VSV vectors are promising candidates for human AIDS vaccine trials because they propagate to high titers and can be delivered without injection.

publication date

  • September 7, 2001

Research

keywords

  • AIDS Vaccines
  • Acquired Immunodeficiency Syndrome
  • Vesicular stomatitis Indiana virus

Identity

Scopus Document Identifier

  • 17944369239

Digital Object Identifier (DOI)

  • 10.1016/s0092-8674(01)00482-2

PubMed ID

  • 11551502

Additional Document Info

volume

  • 106

issue

  • 5