Long-term treatment with recombinant nerve growth factor for HIV-associated sensory neuropathy. Academic Article uri icon

Overview

abstract

  • HIV-associated distal sensory polyneuropathy (DSP) is a common complication of AIDS. No effective treatment is available. The authors investigated the long-term effect (48 weeks) of the neurotrophin nerve growth factor (NGF) in an open-label study of 200 subjects with HIV-associated DSP. Similar to their previously reported double-blind study, the authors showed that NGF was safe and well tolerated and significantly improved pain symptoms. However, there was no improvement of neuropathy severity as assessed by neurologic examination, quantitative sensory testing, and epidermal nerve fiber density.

publication date

  • October 9, 2001

Research

keywords

  • Acquired Immunodeficiency Syndrome
  • Nerve Growth Factor
  • Peripheral Nervous System Diseases

Identity

Scopus Document Identifier

  • 0035833962

Digital Object Identifier (DOI)

  • 10.1212/wnl.57.7.1313

PubMed ID

  • 11591856

Additional Document Info

volume

  • 57

issue

  • 7