Dissociation of prolactin response to thyrotropin-releasing hormone and metoclopramide in chronic renal failure. Academic Article uri icon

Overview

abstract

  • PRL secretion was evaluated in 14 males with chronic renal failure on long term hemodialysis. Twelve had basal hyperprolactinemia. Ten subjects were challenged with TRH in doses ranging from 200--1000 micrograms. None of them responded to 200 or 500 micrograms TRH, although 2 of 4 subjects tested did respond to 1000 micrograms TRH. In contrast, all 4 subjects challenged with metoclopramide did have PRL responses which were indistinguishable from those of the controls. These results indicate that there is a dissociation in responsiveness to metoclopramide and TRH in chronic renal failure.

publication date

  • December 1, 1979

Research

keywords

  • Kidney Failure, Chronic
  • Metoclopramide
  • Prolactin
  • Thyrotropin-Releasing Hormone

Identity

Scopus Document Identifier

  • 0018568647

Digital Object Identifier (DOI)

  • 10.1210/jcem-49-6-815

PubMed ID

  • 117018

Additional Document Info

volume

  • 49

issue

  • 6