Hypermagnesemia does not increase brain intracellular magnesium in newborn swine. Academic Article uri icon

Overview

abstract

  • Phosphorus-31 magnetic resonance spectroscopy was used in 2-day (n = 4) and 40-day (n = 4) miniswine to determine whether plasma hypermagnesemia alters brain intracellular magnesium concentration and if the plasma-brain intracellular magnesium relationship changes with age. At control, brain intracellular magnesium concentration was similar in the 2-day (0.24 +/- 0.04 mM) and 40-day groups (0.21 +/- 0.01 mM). Intravenous infusions of magnesium sulfate (MgSO(4), 60 minute) raised plasma magnesium concentration to 4-6 mM in both groups. During and for 3 hours after MgSO(4) infusions, there were no changes in brain intracellular magnesium concentration in either group and no correlation between plasma and brain intracellular magnesium (r = 0.11 and 0.08 for 2- and 40-day groups, respectively). Brain intracellular magnesium concentration appears to be tightly regulated.

publication date

  • October 1, 2001

Research

keywords

  • Blood-Brain Barrier
  • Brain Chemistry
  • Magnesium
  • Magnesium Sulfate
  • Neuroprotective Agents

Identity

Scopus Document Identifier

  • 0034751373

Digital Object Identifier (DOI)

  • 10.1016/s0887-8994(01)00317-4

PubMed ID

  • 11704399

Additional Document Info

volume

  • 25

issue

  • 4