Augmentation of tendon healing in an intraarticular bone tunnel with use of a bone growth factor. Academic Article uri icon

Overview

abstract

  • We hypothesized that an exogenous bone growth factor could augment healing of a tendon graft in a bone tunnel in a rabbit anterior cruciate ligament-reconstruction model. Seventy rabbits underwent bilateral anterior cruciate ligament reconstructions with a semitendinosus tendon graft. One limb received a collagen sponge carrier vehicle containing a mixture of bone-derived proteins while the contralateral limb was treated with either no sponge or a sponge without bone-derived proteins. The reconstruction was evaluated at 2, 4, or 8 weeks with histologic, biomechanical, and magnetic resonance imaging analysis. Histologic analysis demonstrated that specimens treated with bone-derived proteins had a more consistent, dense interface tissue and closer apposition of new bone to the graft, with occasional formation of a fibrocartilaginous interface, when compared with control specimens. The treated specimens had significantly higher load-to-failure rates than did control specimens. Treatment with bone-derived proteins resulted in an average increase in tensile strength of 65%. The treated specimens were stronger than control specimens at each time point, but the difference was greatest at 8 weeks. On the basis of signal characteristics and new bone formation, magnetic resonance imaging was useful for predicting which limb was treated, the site of failure, and the limbs with higher load-to-failure values. This study demonstrates the potential for augmenting tendon healing in an intraarticular bone tunnel using an osteoinductive growth factor.

publication date

  • January 1, 2001

Research

keywords

  • Anterior Cruciate Ligament Injuries
  • Bone Morphogenetic Proteins
  • Tendons
  • Wound Healing

Identity

Scopus Document Identifier

  • 0035169913

Digital Object Identifier (DOI)

  • 10.1177/03635465010290060301

PubMed ID

  • 11734478

Additional Document Info

volume

  • 29

issue

  • 6