The respiratory rhythm in mutant oscillator mice. Academic Article uri icon

Overview

abstract

  • Since glycinergic inhibition is important for respiratory rhythm generation in mature mammals, we tested the hypothesis that the loss of glycine receptors during postnatal development (P17-P23) of homozygous mutant oscillator mice (spd(ot)/spd(ot)) may result in serious impairment of respiratory rhythm. We measured breathing in a plethysmographic recording chamber on conscious oscillator mice and used an in situ perfused brainstem preparation to record phrenic nerve activity, as well as membrane properties of respiratory neurones. The deletion of glycinergic inhibition did not result in failure of respiratory rhythm: homozygous mutant oscillator mice continue to generate a disturbed respiratory rhythm until death. Postsynaptic activity and membrane potential trajectories of respiratory neurones revealed a persistence of GABAergic inhibition and changes in respiratory rhythm and pattern generation.

publication date

  • December 1, 2001

Research

keywords

  • Nerve Net
  • Neural Inhibition
  • Neurons
  • Receptors, Glycine
  • Respiratory Center
  • Respiratory Insufficiency

Identity

Scopus Document Identifier

  • 0035909988

Digital Object Identifier (DOI)

  • 10.1016/s0304-3940(01)02382-5

PubMed ID

  • 11742725

Additional Document Info

volume

  • 316

issue

  • 2