Influence of graft ischemic time on outcomes following lung transplantation. Academic Article uri icon

Overview

abstract

  • BACKGROUND: Reperfusion injury is the most common cause of early mortality following lung transplantation. Although cold graft ischemic time has been reported to influence this injury, some lung grafts with short ischemic times develop significant reperfusion injury, whereas other grafts with more prolonged ischemic times do not develop injury. Our hypothesis was that ischemic time did not significantly influence reperfusion injury or other outcomes following lung transplantation. METHODS: Data on 136 patients who had lung transplantation over a 10 year period was used for analysis. RESULTS: Cold graft ischemic time > or = 6 hours did not increase the risk of reperfusion injury, acute rejection, cytomegalovirus infection, bacterial or fungal pneumonia, bronchiolitis obliterans syndrome, 1-month mortality, 1-year mortality, or 5-year mortality compared with ischemic times of either < 4 hours or 4 to 6 hours. The incidence of reperfusion injury was at least 20% for each time group. CONCLUSIONS: At least 20% of all patients will develop reperfusion injury regardless of cold graft ischemic time. Prolonged ischemic times up to 8 hours do not result in a significant increase in adverse short-term, intermediate, or long-term outcomes. Cautious extension of ischemic time beyond the current target of 4 to 6 hours may be warranted for geographic expansion of the donor lung pool.

publication date

  • December 1, 2001

Research

keywords

  • Cryopreservation
  • Lung
  • Lung Transplantation
  • Organ Preservation
  • Reperfusion Injury

Identity

Scopus Document Identifier

  • 0035667625

Digital Object Identifier (DOI)

  • 10.1016/s1053-2498(01)00355-2

PubMed ID

  • 11744412

Additional Document Info

volume

  • 20

issue

  • 12