Patterns of muscle involvement in inclusion body myositis: clinical and magnetic resonance imaging study. Academic Article uri icon

Overview

abstract

  • The differential patterns of muscle involvement in the upper and lower limbs in sporadic inclusion body myositis (sIBM) were examined in 18 patients using both quantitative and manual muscle testing as well as magnetic resonance imaging (MRI) in 9 patients. Weakness of the quadriceps femoris and the forearm flexors was present in most patients, but there was considerable variability in the patterns and severity of muscle involvement. MRI disclosed preferential patterns of muscle involvement within functional groups such as the quadriceps femoris, in which there was severe involvement of the vasti with relative sparing of the rectus femoris, and the triceps surae, in which selective involvement of the medial gastrocnemius was common. Involvement of flexor digitorum profundus on MRI was found in only one third of patients. The results emphasize the variability in the clinical phenotype and differential susceptibility of muscles to the disease process in sIBM.

publication date

  • November 1, 2001

Research

keywords

  • Magnetic Resonance Imaging
  • Muscle, Skeletal
  • Myositis, Inclusion Body

Identity

Scopus Document Identifier

  • 0034778644

Digital Object Identifier (DOI)

  • 10.1002/mus.1178

PubMed ID

  • 11745956

Additional Document Info

volume

  • 24

issue

  • 11