Concentrated autologous plasma protein: a biochemically neutral solder for tissue welding. Academic Article uri icon

Overview

abstract

  • BACKGROUND AND OBJECTIVE: Xenographic or allographic serum protein solders used for laser welding may have immunologic and/or pathogenic complications. The objective of these studies was to develop a safe, autologous solder. STUDY DESIGN/MATERIALS AND METHODS: Five methods of preparing concentrated autologous plasma protein solder (CAPPS) were evaluated. Next, the CAPPS was evaluated via (1) thermal denaturation studies using differential scanning calorimetry, (2) tissue welding studies to characterize both acute and healing properties. RESULTS: The optimal concentration method to produce CAPPS rapidly was a dialysis method using chemical (osmotic) forces. The CAPPS showed similar denaturation profiles to serum albumin (SA) solders. Acutely, CAPPS provided comparable breaking strengths to SA solders. At 7 days, there was no significant difference in breaking strength or histology between 50% human SA solder and CAPPS (using a porcine skin model). CONCLUSIONS: These studies demonstrate that the CAPPS system provides acceptable acute and chronic properties for laser welding.

publication date

  • January 1, 2001

Research

keywords

  • Blood Proteins
  • Intestine, Small
  • Laser Therapy
  • Tissue Adhesives
  • Welding

Identity

Scopus Document Identifier

  • 0034761589

Digital Object Identifier (DOI)

  • 10.1002/lsm.1126

PubMed ID

  • 11746111

Additional Document Info

volume

  • 29

issue

  • 4