Synthesis and characterization of (99m)Tc- and (188)Re-complexes with a diamido-dihydroxymethylenephosphine-based bifunctional chelating agent (N(2)P(2)-BFCA). Academic Article uri icon

Overview

abstract

  • A diamido-dihydroxymethylenephosphine (N(2)P(2)) bifunction chelating agent (BFCA) was shown to form well-defined (99m)Tc- and (188)Re-chelate structures. The 4, 4-bis [bis-hydroxymethyl-phosphonyl-propylcarbonmoyl]-butyric acid bifunctional chelating agent (N(2)P(2)-BFCA) formed stable complexes with (99m)Tc and (188)Re in >95% yield with high radiochemical purity (RCP). The biodistribution of the (99m)Tc- and (188)Re-N(2)P(2)-BFCAs after intravenous injection studied in normal mice showed the activity was excreted primarily via renal-urinary pathway indicating their use for labeling peptides with (99m)Tc and (188)Re.

publication date

  • January 1, 2002

Research

keywords

  • Chelating Agents
  • Rhenium
  • Technetium Compounds

Identity

Scopus Document Identifier

  • 0036148047

Digital Object Identifier (DOI)

  • 10.1016/s0969-8051(01)00280-3

PubMed ID

  • 11786279

Additional Document Info

volume

  • 29

issue

  • 1