Effect of pneumatic compression on fibrinolysis after total hip arthroplasty. Academic Article uri icon

Overview

abstract

  • The purpose of this prospective randomized clinical study was to investigate the enhanced systemic fibrinolysis mechanism of venous thrombosis prevention by pneumatic compression after total hip arthroplasty. Fifty patients were randomized into one of two groups (one with pneumatic compression [n=25] and one without [n=25]). Blood was drawn from a radial arterial line immediately preoperatively (baseline), at skin closure, and 8 hours and 22 hours after the baseline sample. Serum determinations of antigen of tissue plasminogen activator and plasminogen activator inhibitor-1 were done using enzyme-linked immunosorbent assays. These data do not support the enhancement of systemic fibrinolysis mechanism for lowering thromboembolic risk after total hip arthroplasty by pneumatic compression devices. The results of this study showed no differences that were statistically significant between the two groups. The greatest difference was observed 8 hours after surgery for the plasminogen activator inhibitor-1 marker, (28.12 with compression versus 22.07 ng/mL without); however, this result was not statistically significant. The beneficial effect of mechanical compression is more likely achieved through increased flow, local fibrinolytic effects, or both.

publication date

  • June 1, 2002

Research

keywords

  • Arthroplasty, Replacement, Hip
  • Bandages
  • Fibrinolysis
  • Plasminogen Activator Inhibitor 1
  • Postoperative Care
  • Venous Thrombosis

Identity

Scopus Document Identifier

  • 0036271526

Digital Object Identifier (DOI)

  • 10.1097/00003086-200206000-00020

PubMed ID

  • 12011706

Additional Document Info

issue

  • 399