Gene therapy for prostate cancer. Review uri icon

Overview

abstract

  • Prostate cancer is the most common noncutaneous cancer in man. When confined to the prostate it can be cured by radical prostatectomy or irradiation therapy. However, there are no curative therapies for locally advanced, recurrent or metastatic disease. Prostate cancer gene therapy has recently transition from preclinical studies to clinical trials with the goal of developing novel treatments for prostate cancer. The greatest challenge in treating advanced prostate cancer is therapeutic access to and the elimination of metastases. This review details two aspects of prostate cancer gene therapy, the types of delivery systems under development and specific categories of therapeutic genes available with an emphasis on the mechanism of action of specific gene therapy strategies.

publication date

  • June 1, 2002

Research

keywords

  • Adjuvants, Immunologic
  • Genes, Tumor Suppressor
  • Genetic Therapy
  • Prostatic Neoplasms

Identity

Scopus Document Identifier

  • 0036081075

Digital Object Identifier (DOI)

  • 10.1586/14737140.2.3.309

PubMed ID

  • 12113054

Additional Document Info

volume

  • 2

issue

  • 3