Animal models for preclinical assessment of bone morphogenetic proteins in the spine. Review uri icon

Overview

abstract

  • STUDY DESIGN: A review of the rationale behind the use of animal models for the assessment of bone morphogenetic proteins (BMPs) in the spine. OBJECTIVE: To summarize the underlying principles of animal experimentation in the context of bone morphogenetic proteins and the spine. SUMMARY OF BACKGROUND DATA: Animal models aid in the collection of important information regarding the precise mechanobiologic events that occur during spinal fusion healing. Reproducible spinal fusion models have been developed in several animal species, leading to experimentation in a controlled fashion. Reliable assessment of outcome measures for osseous healing, including histology and biomechanical testing, has made preclinical testing of innovative growth factors essential before the advance to clinical trials. METHODS: These materials have initially gone through the "burden of proof" steps: proof of concept studies, feasibility studies, and efficacy studies. RESULTS AND CONCLUSIONS: Bone morphogenetic proteins have undergone extensive scrutiny in the preclinical arena. This article summarizes the evolution of animal experimentation with BMP including the background and future directions.

publication date

  • August 15, 2002

Research

keywords

  • Bone Morphogenetic Proteins
  • Lumbar Vertebrae
  • Osteogenesis

Identity

Scopus Document Identifier

  • 0037102488

Digital Object Identifier (DOI)

  • 10.1097/00007632-200208151-00008

PubMed ID

  • 12205417

Additional Document Info

volume

  • 27

issue

  • 16 Suppl 1