The influence of metiamide on ouabain cardiotoxicity. Academic Article uri icon

Overview

abstract

  • The effect of metiamide on the cardiotoxicity produced by ouabain was studied in pentobarbital-anesthetized cats. The onset of ouabain-induced ventricular tachycardia and fibrillation was significantly delayed in cats treated with metiamide as compared with cats that did not receive metiamide. Although the mechanism by which metiamide inhibits ouabain toxicity is speculative, the data suggest that histamine H2-receptor blocking agents may be useful as anti-arrhythmic drugs in digitalis cardiotoxicity.

publication date

  • November 1, 1975

Research

keywords

  • Heart
  • Metiamide
  • Ouabain
  • Thiourea

Identity

Scopus Document Identifier

  • 0016709626

Digital Object Identifier (DOI)

  • 10.1016/0014-2999(75)90245-9

PubMed ID

  • 1234766

Additional Document Info

volume

  • 34

issue

  • 1