Selective impairment of atrioventricular conduction by 2-(2-pyridyl)-ethylamine and 2-(2-thiazolyl)-ethylamine, two histamine H1-receptor agonists. Academic Article uri icon

Overview

abstract

  • To further characterize the receptor mediating histamine-induced impairment of atrioventricular conduction, the effects of two selective histamine H1-receptor agonists, 2-(2-pyridyl)-ethylamine (PEA) and 2-(2-thiazolyl)-ethylamine (ThEA), were investigated using the isolated guinea pig heart. These effects were compared with those of histamine and other selective agonists. PEA and ThEA produced a weak stimulation of cardiac rate and contractility; however, they produced a marked prolongation of atrioventricular conduction. The orders of relative potencies observed substantiate the hypothesis that H2-receptors mediate the positive inotropic and chronotropic effects and H1-receptors mediate the negative dromotropic effect of histamine.

publication date

  • November 1, 1975

Research

keywords

  • Ethylamines
  • Heart Conduction System
  • Receptors, Histamine
  • Receptors, Histamine H1

Identity

Scopus Document Identifier

  • 0016816845

Digital Object Identifier (DOI)

  • 10.1016/0014-2999(75)90246-0

PubMed ID

  • 1234767

Additional Document Info

volume

  • 34

issue

  • 1