Breast-conservation therapy in early-stage breast cancer patients with a positive family history. Academic Article uri icon

Overview

abstract

  • BACKGROUND: Our goal was to evaluate the role of breast-conservation therapy in early-stage breast cancer patients with a family history (FH) of breast cancer. METHODS: Between 1970 and 1994, 1324 female patients with breast cancer were treated with breast-conservation therapy at our institution. From these, we identified 985 patients with stage 0-II breast cancer and who had available information on FH status. FH was considered positive in any patient who had a relative who had been previously diagnosed with breast cancer. Disease-specific survival was calculated from the date of initial diagnosis using the Kaplan-Meier method. RESULTS: The stage distribution for the 985 patients was as follows: 0 in 65 (7%), I in 500 (51%), and II in 420 (43%). The median age was 50 years (range, 21-88), with a median follow-up time of 8.8 years (range,.25-29). The median tumor size was 1.5 cm. FH was positive in 31%. There were no significant differences in locoregional recurrence, distant recurrence, disease-specific survival, or incidence of contralateral breast cancer in patients with a positive FH versus patients with a negative FH. CONCLUSIONS: Breast-conservation therapy is not contraindicated in early-stage breast cancer patients with a positive FH.

publication date

  • November 1, 2002

Research

keywords

  • Breast Neoplasms
  • Carcinoma, Ductal, Breast
  • Mastectomy, Segmental

Identity

Scopus Document Identifier

  • 0036841067

Digital Object Identifier (DOI)

  • 10.1007/BF02557530

PubMed ID

  • 12417515

Additional Document Info

volume

  • 9

issue

  • 9