Targeting tumours with genetically enhanced T lymphocytes. Review uri icon

Overview

abstract

  • The genetic modification of T lymphocytes is an important approach to investigating normal T-cell biology and to increasing antitumour immunity. A number of genetic strategies aim to increase the recognition of tumour antigens, enhance antitumour activities and prevent T-cell malfunction. T cells can also be engineered to increase safety, as well as to express markers that can be tracked by non-invasive imaging technologies. Genetically modified T cells are therefore proving to be of great value for basic immunology and experimental immunotherapy.

publication date

  • January 1, 2003

Research

keywords

  • Immunotherapy
  • Neoplasms
  • T-Lymphocytes

Identity

Scopus Document Identifier

  • 0037264471

Digital Object Identifier (DOI)

  • 10.1038/nrc971

PubMed ID

  • 12509765

Additional Document Info

volume

  • 3

issue

  • 1