Role of CD8(+) lymphocytes in control and clearance of measles virus infection of rhesus monkeys. Academic Article uri icon

Overview

abstract

  • The creation of an improved vaccine for global measles control will require an understanding of the immune mechanisms of measles virus containment. To assess the role of CD8(+) cytotoxic T lymphocytes in measles virus clearance, rhesus monkeys were depleted of CD8(+) lymphocytes by monoclonal anti-CD8 antibody infusion and challenged with wild-type measles virus. The CD8(+) lymphocyte-depleted animals exhibited a more extensive rash, higher viral loads at the peak of virus replication, and a longer duration of viremia than did the control antibody-treated animals. These findings indicate a central role for CD8(+) lymphocytes in the control of measles virus infections and the importance of eliciting a cell-mediated immune response in new measles vaccine strategies.

authors

  • Permar, Sallie
  • Klumpp, Sherry A
  • Mansfield, Keith G
  • Kim, Woong-Ki
  • Gorgone, Darci A
  • Lifton, Michelle A
  • Williams, Kenneth C
  • Schmitz, Jörn E
  • Reimann, Keith A
  • Axthelm, Michael K
  • Polack, Fernando P
  • Griffin, Diane E
  • Letvin, Norman L

publication date

  • April 1, 2003

Research

keywords

  • CD8-Positive T-Lymphocytes
  • Measles
  • Measles virus

Identity

PubMed Central ID

  • PMC150640

Scopus Document Identifier

  • 0037377748

Digital Object Identifier (DOI)

  • 10.1128/jvi.77.7.4396-4400.2003

PubMed ID

  • 12634396

Additional Document Info

volume

  • 77

issue

  • 7