Clinically inapparent invasive vulvar carcinoma in an area of persistent Paget's disease: a case report. uri icon

Overview

abstract

  • BACKGROUND: Invasive vulvar carcinoma is reported to occur in 5 to 20% of patients with vulvar Paget's disease. We report a case in which a clinically inapparent invasive lesion was discovered on reexcision of microscopically persistent vulvar Paget's disease. CASE: A 58-year-old woman presented with a diagnosis of vulvar Paget's disease. A wide local excision of the lesion was performed and pathologic analysis revealed microscopic Paget's disease at two of the margins. The patient returned for a follow-up 4 months later and a vulvar biopsy revealing persistent Paget's cells was obtained from the area of the prior microscopically positive surgical margin. A reexcision was performed from the normal-appearing vulva and invasive vulvar carcinoma was noted in this specimen. CONCLUSIONS: This case demonstrates several concerning aspects of this disease, most important of which is that the clinically apparent lesion did not contain the clinically significant invasive lesion. Invasive vulvar carcinoma may occur in association with microscopically persistent vulvar Paget's disease, a condition often encountered after primary treatment with wide local excision.

publication date

  • March 1, 2003

Research

keywords

  • Paget Disease, Extramammary
  • Vulvar Neoplasms

Identity

Scopus Document Identifier

  • 0037340771

Digital Object Identifier (DOI)

  • 10.1016/s0090-8258(02)00007-0

PubMed ID

  • 12648600

Additional Document Info

volume

  • 88

issue

  • 3