Histopathologic type: an independent prognostic factor in primary soft tissue sarcoma of the extremity? Academic Article uri icon

Overview

abstract

  • BACKGROUND: We attempted to define the effect of tumor histotype on local recurrence, distant metastasis, and disease-specific survival in patients with surgically treated primary extremity sarcoma. METHODS: A total of 951 patients with primary, localized soft tissue extremity sarcoma were followed up prospectively. Patient- and tumor-related variables, including histopathologic type, were used to identify independent prognostic factors for the study end points of local recurrence, distant recurrence, and disease-specific survival. RESULTS: There were 137 local recurrences, and significant adverse prognostic factors for local recurrence were patient age >50 years, microscopically positive margins, and malignant peripheral nerve tumor. Adverse prognostic factors for distant recurrence (200 patients) were tumor size >5 cm, tumors beneath the investing fascia, high tumor grade, and leiomyosarcoma. Of the 199 patients who died of disease-related causes, patient age >50 years, tumors beneath the investing fascia, high tumor grade, microscopically positive margin, tumor size >5 cm, leiomyosarcoma, and malignant peripheral nerve tumor were adverse prognostic factors. CONCLUSIONS: These data suggest that differences in biological behavior may exist between sarcoma histotypes and deserve further study.

publication date

  • May 1, 2003

Research

keywords

  • Neoplasm Recurrence, Local
  • Sarcoma
  • Soft Tissue Neoplasms

Identity

Scopus Document Identifier

  • 0041660560

Digital Object Identifier (DOI)

  • 10.1245/aso.2003.05.014

PubMed ID

  • 12734093

Additional Document Info

volume

  • 10

issue

  • 4