Acquired hemophilia A after liver transplantation: a case report. Academic Article uri icon

Overview

abstract

  • It is well recognized that orthotopic liver transplantation rapidly corrects the coagulation disorder observed in patients with hemophilia A or B combined with end-stage liver disease; however, the transmission of hemophilia from a donor to a transplant recipient has not been reported previously. We describe a patient who developed acquired hemophilia A after liver transplantation due to the unknown presence of factor VIII inhibitor in the donor. The resulting coagulation disorder was unresponsive to standard factor replacement therapy, and was ultimately corrected with retransplantation. Hemophiliac donors should not be precluded from organ donation, though the presence of factor VIII inhibitor should be actively sought before organ procurement. High levels of factor VIII inhibitor represents an absolute contraindication to liver donation.

publication date

  • May 1, 2003

Research

keywords

  • Hemophilia A
  • Hepatitis C, Chronic
  • Liver Transplantation

Identity

Scopus Document Identifier

  • 0037767365

Digital Object Identifier (DOI)

  • 10.1053/jlts.2003.50095

PubMed ID

  • 12740798

Additional Document Info

volume

  • 9

issue

  • 5