Functional genomics guided with MR imaging: mouse tumor model study. Academic Article uri icon

Overview

abstract

  • To gain a better understanding of gene expression patterns in tumors, the authors used contrast material-enhanced magnetic resonance (MR) imaging to noninvasively characterize regions within the same tumor to provide a correlate for genomic analysis. Gene expression profiles of samples from a mouse tumor model obtained from contrast-enhanced and nonenhanced regions within the same tumor were compared with MR imaging and functional genomics. From these samples, 11000 genes were analyzed: 10 genes were up-regulated in the contrast-enhanced areas, and one gene was up-regulated in the nonenhanced regions. Several of these genes encode extracellular matrix proteins. Findings in this study demonstrate that MR imaging can serve as a powerful noninvasive tool for characterizing different regions of tumors to guide genomic analysis with high spatial and temporal resolution.

publication date

  • June 23, 2003

Research

keywords

  • Carcinoma, Squamous Cell
  • Gene Expression Profiling
  • Magnetic Resonance Imaging

Identity

Scopus Document Identifier

  • 0042844532

Digital Object Identifier (DOI)

  • 10.1148/radiol.2282020907

PubMed ID

  • 12821773

Additional Document Info

volume

  • 228

issue

  • 2