Intra-tumoral distribution of (64)Cu-ATSM: a comparison study with FDG. Academic Article uri icon

Overview

abstract

  • (64)Cu-labeled diacetyl-bis(N(4)-methylthiosemicarbazone) ((64)Cu-ATSM) is a promising agent for internal radiation therapy and imaging of hypoxic tissues. In the present study, the intra-tumoral distribution of (64)Cu-ATSM was investigated by comparing it to that of [(18)F]FDG and histological findings. VX2 tumors were implanted into Japanese white rabbits subcutaneously. (64)Cu-ATSM and [(18)F]FDG were co-injected intravenously and the tumor was dissected and cut into 1 mm thick slices 1 h after the injection. The uptake of (64)Cu-ATSM and [(18)F]FDG was measured using a dual-tracer autoradiographic technique. Histological cell biology was estimated from the optical microscopy of tumor sections. The major accumulation of (64)Cu-ATSM was observed around the outer rim of the tumor masses which consisted mainly of active cells and expected to be hypoxic. [(18)F]FDG was distributed more widely with highest levels in the inner regions where pre-necrotic cells were mainly observed. (64)Cu-ATSM appears to be useful for the detection of hypoxic but active tumor cell regions in vivo.

publication date

  • July 1, 2003

Research

keywords

  • Copper Radioisotopes
  • Fluorodeoxyglucose F18
  • Liver Neoplasms, Experimental
  • Organometallic Compounds
  • Thiosemicarbazones

Identity

Scopus Document Identifier

  • 12444338955

Digital Object Identifier (DOI)

  • 10.1016/s0969-8051(03)00047-7

PubMed ID

  • 12831991

Additional Document Info

volume

  • 30

issue

  • 5