The camptothecins. Review uri icon

Overview

abstract

  • Supported by detailed understanding of their mechanism of action, and facilitated by chemical manipulations that have amplified their solubility, the camptothecins have advanced to the forefront of several areas of therapeutic and developmental chemotherapy. Additive and synergistic laboratory interactions with other cytotoxic drugs have been exploited to allow development of camptothecin-based multidrug regimens, which are showing important activity in several malignancies. Topotecan and irinotecan are already in widespread use in clinical practice, and newer agents with promising preclinical activity are in various stages of clinical assessment. As knowledge of molecular and biochemical mechanisms of action and resistance continues to expand, newer and better camptothecin-based strategies for treatment of malignant disease are likely to evolve.

publication date

  • June 28, 2003

Research

keywords

  • Antineoplastic Agents, Phytogenic
  • Camptothecin

Identity

Scopus Document Identifier

  • 0038167666

Digital Object Identifier (DOI)

  • 10.1016/S0140-6736(03)13780-4

PubMed ID

  • 12842380

Additional Document Info

volume

  • 361

issue

  • 9376