Sex ratio and rheumatic disease. Review uri icon

Overview

abstract

  • Some thyroid, rheumatic and hepatic diseases consistently have high female:male ratios, but many autoimmune diseases do not. Gonadal hormones, if they play a role in determining sex ratios, likely do so through a threshold or permissive mechanism. Sex differences related to X-inactivation, imprinting, X or Y chromosome genetic modulators, and intrauterine influences, exposures, vulnerable periods, or thresholds are alternative, theoretical, explanations for sex differences of incidence.

publication date

  • May 1, 2002

Research

keywords

  • Autoimmunity
  • Rheumatic Diseases
  • Sex Ratio

Identity

Scopus Document Identifier

  • 1542509675

Digital Object Identifier (DOI)

  • 10.1016/s1568-9972(02)00034-4

PubMed ID

  • 12849010

Additional Document Info

volume

  • 1

issue

  • 3