Dendritic ribosomes suggest local protein synthesis during estrous synaptogenesis. Academic Article uri icon

Overview

abstract

  • Synapse number and dendritic spine number fluctuate across the estrous cycle in the hippocampal CA1 stratum radiatum. The synaptogenesis phase of estrous is driven by estrogen and may require newly synthesized proteins. Ribosomes synthesize soluble proteins when free in the cytoplasm, and integral membrane or secretory proteins when membrane-associated. Here we report that ribosomal immunoreactivity and the percentage associated with membranes increases locally in dendrites of the CA1 stratum radiatum during estrogen-induced synaptogenesis. These findings are consistent with a role for estrogen in regulating the local synthesis of integral membrane proteins, e.g. receptors, in dendrites for newly developing synapses across the estrous cycle.

publication date

  • July 18, 2003

Research

keywords

  • Dendrites
  • Estrous Cycle
  • Hippocampus
  • Protozoan Proteins
  • Ribosomes
  • Synapses

Identity

Scopus Document Identifier

  • 0042200247

Digital Object Identifier (DOI)

  • 10.1097/01.wnr.0000078380.40088.99

PubMed ID

  • 12876473

Additional Document Info

volume

  • 14

issue

  • 10