Antiretroviral-associated liver injury. Review uri icon

Overview

abstract

  • ART-related hepatotoxicity can manifest in a variety of ways. Although benign, asymptomatic LEEs predominate, liver injury occurring in the context of either hypersensitivity or hyperlactatemia, represents a medical emergency and mandates immediate cessation of ART. Underpinning this broad spectrum of presentations are several, as yet poorly understood, mechanisms of liver damage that reflect contributions by constituents of HAART and host factors. Thus far, the most significant predisposing condition to emerge from clinical studies is chronic viral hepatitis. A more precise understanding, however, of the processes and factors that underlie ART-related hepatotoxicity is critical not only to the management of liver injury from current antiretroviral drugs but also to the design of safer drugs in the future.

publication date

  • May 1, 2003

Research

keywords

  • Anti-HIV Agents
  • Antiretroviral Therapy, Highly Active
  • Chemical and Drug Induced Liver Injury, Chronic

Identity

Scopus Document Identifier

  • 0038385190

Digital Object Identifier (DOI)

  • 10.1016/s1089-3261(03)00023-0

PubMed ID

  • 12879995

Additional Document Info

volume

  • 7

issue

  • 2