Double incision wound healing bioassay using Hamelia patens from El Salvador. Academic Article uri icon

Overview

abstract

  • Hamelia patens Jacq. (Rubiaceae) has received little attention in the laboratory for its wound healing ability even though it is commonly used as a treatment for wounds throughout Central America. A double incision wound healing bioassay was carried out with a crude extract of Hamelia patens collected from El Salvador. Animals were divided into three groups. Group I (n = 14) had the left incision treated with 5% (w/w) Hamelia patens and the contralateral side with petroleum jelly (PJ). Group II (n = 14) had the left incision treated with 10% (w/w) ointment and the contralateral side with petroleum jelly. Group III (n = 10) had the left incision treated with petroleum jelly and the contralateral side left untreated. Breaking strength of the incisions was measured on day 7 and day 12. For Groups I and II, there was no significant difference between treatment and control incisions at day 7. On day 12, there was a significant difference between the treated and control incisions for Groups I and II. There was no significant difference between petroleum jelly and untreated incisions for Group III on day 7 and day 12. Hamelia patens does increase breaking strength of wounds significantly more than the control group. Further wound healing studies of this plant are warranted.

publication date

  • October 1, 2003

Research

keywords

  • Hamelia
  • Medicine, Traditional
  • Wound Healing

Identity

Scopus Document Identifier

  • 0042831213

Digital Object Identifier (DOI)

  • 10.1016/s0378-8741(03)00209-5

PubMed ID

  • 12963138

Additional Document Info

volume

  • 88

issue

  • 2-3