Effect of hyperinsulinemia on whole body and skeletal muscle leucine carbon kinetics in humans. Academic Article uri icon

Overview

abstract

  • Data documenting the isolated effect of systemic hyperinsulinemia on whole body and skeletal muscle leucine carbon kinetics in humans are limited. Using steady-state [14C]leucine kinetics, 10 normal volunteers were studied in the baseline postabsorptive state and then under euglycemic, hyperinsulinemic (71 +/- 5 microU/ml), and euleucinemic conditions. Systemic hyperinsulinemia resulted in a significant decrease in whole body and forearm leucine rate of appearance (Ra) by 17 and 37%, respectively, (P less than 0.0003, 0.03), without a significant change in the nonoxidized rate of disappearance for either (P = 0.23, 0.66). The baseline contribution of total body skeletal muscle (TBSM) leucine Ra and rate of disappearance (Rd) to whole body leucine Ra and Rd was 27 +/- 6 and 24 +/- 5%, respectively. During hyperinsulinemia TBSM Ra decreased by 34%, whereas whole body Ra decreased by 16%. We conclude that the primary effect of insulin in the whole body and skeletal muscle is to decrease leucine release from protein without a significant effect on leucine incorporation into protein. This antiproteolytic effect of insulin is more pronounced in skeletal muscle than in other tissues in the body.

publication date

  • June 1, 1992

Research

keywords

  • Amino Acids
  • Hyperinsulinism
  • Insulin
  • Leucine
  • Muscles

Identity

Scopus Document Identifier

  • 0026636463

Digital Object Identifier (DOI)

  • 10.1152/ajpendo.1992.262.6.E911

PubMed ID

  • 1319683

Additional Document Info

volume

  • 262

issue

  • 6 Pt 1