High dose rate gynecological applications--radiobiological considerations based on the alpha-beta model. Academic Article uri icon

Overview

abstract

  • We compare the relative efficacy of high dose rate (HDR) and low dose rate (LDR) irradiation in gynecological implants, using formulations based on the linear-quadratic (alpha-beta) model. We consider both acute reaction and late effect as endpoints in evaluating equivalence for HDR and LDR treatments, at Point A (as defined in the text) and at other locations. We define a therapeutic factor gamma as an index for relative efficacy, with gamma > 1 indicating a gain in substituting HDR for LDR. It is found that gamma < 1 for most clinical situations, although a modest decrease (of about 15%) in dose to critical organs for HDR would raise gamma above unity.

publication date

  • October 1, 1992

Research

keywords

  • Brachytherapy
  • Genital Neoplasms, Female

Identity

Scopus Document Identifier

  • 0026498032

Digital Object Identifier (DOI)

  • 10.1016/0167-8140(92)90016-n

PubMed ID

  • 1438929

Additional Document Info

volume

  • 25

issue

  • 2