Preparation of 66Ga- and 68Ga-labeled Ga(III)-deferoxamine-folate as potential folate-receptor-targeted PET radiopharmaceuticals. Academic Article uri icon

Overview

abstract

  • A folate-receptor-targeting radiopharmaceutical, Ga(III)-deferoxamine-folate (Ga-DF-Folate), was radiolabeled with two positron-emitting isotopes of gallium, cyclotron-produced (66)Ga (9.5 hour half-life) and generator-produced (68)Ga (68 minute half-life). The [(66)Ga]Ga-DF-Folate was administered to athymic mice with folate-receptor-positive human KB cell tumor xenografts to demonstrate that microPET mouse tumor imaging is feasible with (66)Ga, despite the relatively high positron energy of this radionuclide. Using the athymic mouse KB tumor xenograft model, dual-isotope autoradiography was also performed following i.v. co-administration of [(18)F]-FDG, a marker of regional metabolic activity, and folate-receptor-targeted [(111)In]In-DTPA-Folate. The autoradiographic images of 1 mm tumor sections demonstrate the gross heterogeneity of the KB cell tumor xenograft, as well as subtle disparity in the regional accumulation of the two radiotracers.

publication date

  • October 1, 2003

Research

keywords

  • Carrier Proteins
  • Deferoxamine
  • Folic Acid
  • Gallium Radioisotopes
  • Isotope Labeling
  • Neoplasms
  • Receptors, Cell Surface
  • Tomography, Emission-Computed

Identity

Scopus Document Identifier

  • 0141448741

Digital Object Identifier (DOI)

  • 10.1016/s0969-8051(03)00080-5

PubMed ID

  • 14499330

Additional Document Info

volume

  • 30

issue

  • 7