Postoperative nomogram for disease-specific survival after an R0 resection for gastric carcinoma. Academic Article uri icon

Overview

abstract

  • PURPOSE: Few published studies have addressed individual patient risk after R0 resection for gastric cancer. We developed and internally validated a nomogram that combines these factors to predict the probability of 5-year gastric cancer-specific survival on the basis of 1,039 patients treated at a single institution. METHODS: Nomogram predictor variables included age, sex, primary site (distal one-third, middle one-third, gastroesophageal junction, and proximal one-third), Lauren histotype (diffuse, intestinal, mixed), number of positive lymph nodes resected, number of negative lymph nodes resected, and depth of invasion. Death as a result of gastric cancer was the predicted end point. The concordance index was used as an accuracy measure, with bootstrapping to correct for optimistic bias. Calibration plots were constructed. RESULTS: Gastric cancer-specific survival at 5 years was 50%. A nomogram was constructed on the basis of a Cox regression model. The bootstrap-corrected concordance index was 0.80. When compared with the predictive ability of American Joint Committee on Cancer stage, the nomogram discrimination was superior (P <.001). Nomogram calibration appeared to be excellent. CONCLUSION: A nomogram was developed to predict 5-year disease-specific survival after R0 resection for gastric cancer. This tool should be useful for patient counseling, follow-up scheduling, and clinical trial eligibility determination.

publication date

  • October 1, 2003

Research

keywords

  • Lymphatic Metastasis
  • Models, Statistical
  • Neoplasm Invasiveness
  • Stomach Neoplasms

Identity

Scopus Document Identifier

  • 0142008434

Digital Object Identifier (DOI)

  • 10.1200/JCO.2003.01.240

PubMed ID

  • 14512396

Additional Document Info

volume

  • 21

issue

  • 19