New retinoblastoma tumor formation in children initially treated with systemic carboplatin. Academic Article uri icon

Overview

abstract

  • PURPOSE: To determine the frequency and timing of new intraocular tumor formation in children with hereditary retinoblastoma initially treated with systemic carboplatin. DESIGN: Retrospective, noncomparative case series. PARTICIPANTS: This study included 34 children (57 eyes) with hereditary bilateral retinoblastoma initially treated with systemic carboplatin at the Robert M. Ellsworth Ophthalmic Oncology Center at NewYork-Presbyterian Hospital from 1994 through 2000. MAIN OUTCOME MEASURES: New tumor formation after initial treatment with systemic carboplatin. RESULTS: There were a total of 165 tumors in 57 eyes. There were 63 new tumors in 27 eyes (47%) after administration of systemic carboplatin, for a mean of 1.1 new tumors per eye. The mean patient age at time of new tumor presentation was 9 months, with 57% of new tumors developing within 4 months of carboplatin treatment. Kaplan-Meier analysis showed that children who were treated when younger than 6 months of age were more likely to have new tumors (60%) compared with those treated after 6 months of age (31%; P = 0.0182). CONCLUSIONS: New intraocular tumors continue to develop after systemic carboplatin; most new tumors appeared within 4 months of treatment.

publication date

  • October 1, 2003

Research

keywords

  • Antineoplastic Agents
  • Carboplatin
  • Neoplasms, Second Primary
  • Retinal Neoplasms
  • Retinoblastoma

Identity

Scopus Document Identifier

  • 0141747232

Digital Object Identifier (DOI)

  • 10.1016/S0161-6420(03)00669-9

PubMed ID

  • 14522776

Additional Document Info

volume

  • 110

issue

  • 10