CO2 laser urethroplasty in the rabbit: a preclinical model. Academic Article uri icon

Overview

abstract

  • Our previous work has shown that the CO2 laser can be successfully used in urethral reconstruction in a rat model. This new experiment investigates the use of the CO2 laser to perform a patch graft urethroplasty in the rabbit, as a preclinical model to its use in the repair of hypospadias in humans. Using sterile technique, a patch graft of preputial skin was welded in the repair of a standardized urethral defect in 10 rabbits. In another cohort, the same urethral defect was repaired using standard microsuture technique. In a control group the patch graft was placed with microsuture in a nonwatertight fashion. All animals were followed for 3 weeks. Histologic and radiologic analyses were done in a blinded fashion. Our study showed that CO2 laser repair, when compared to microsuture in urethral reconstruction, required 40% less operative time and produced better graft healing and less intraluminal scarring.

publication date

  • January 1, 1992

Research

keywords

  • Laser Therapy
  • Urethra

Identity

Scopus Document Identifier

  • 0026613693

Digital Object Identifier (DOI)

  • 10.1002/lsm.1900120612

PubMed ID

  • 1453867

Additional Document Info

volume

  • 12

issue

  • 6