Comparison between sublobar resection and 125Iodine brachytherapy after sublobar resection in high-risk patients with Stage I non-small-cell lung cancer. Academic Article uri icon

Overview

abstract

  • BACKGROUND: Sublobar resection (SR) can be performed in high-risk non-small-cell lung carcinoma (NSCLC) patients but is associated with an increased local recurrence. This abstract reviews our intraoperative (125)Iodine brachytherapy experience after SR in high-risk Stage I NSCLC patients and compares these results with our previous series of SR alone in similar patients. METHODS: One hundred two Stage I NSCLC patients who underwent SR alone were compared with 101 Stage I patients who underwent SR and intraoperative (125)Iodine brachytherapy placed over the SR staple line. CONCLUSION: Local recurrence after SR and (125)Iodine brachytherapy (2%) in high-risk Stage I NSCLC patients was significantly less than after SR alone (18.6%). This safe, pulmonary function-preserving and practical intraoperative brachytherapy method should be considered when SR is used as a "compromise" therapy in these patients.

authors

  • Michelassi, Fabrizio
  • Santos, Ricardo
  • Colonias, Athanasios
  • Parda, David
  • Trombetta, Mark
  • Maley, Richard H
  • Macherey, Robin
  • Bartley, Susan
  • Santucci, Tibetha
  • Keenan, Robert J
  • Landreneau, Rodney J

publication date

  • October 1, 2003

Research

keywords

  • Brachytherapy
  • Carcinoma, Non-Small-Cell Lung
  • Iodine Radioisotopes
  • Lung
  • Lung Neoplasms

Identity

Scopus Document Identifier

  • 0242719986

Digital Object Identifier (DOI)

  • 10.1016/s0039-6060(03)00327-1

PubMed ID

  • 14605631

Additional Document Info

volume

  • 134

issue

  • 4