Identification and characterization of mouse SSX genes: a multigene family on the X chromosome with restricted cancer/testis expression. Academic Article uri icon

Overview

abstract

  • Human SSX was first identified as the gene involved in the t(X;18) translocation in synovial sarcoma. SSX is a multigene family, with 9 complete genes on chromosome Xp11. Normally expressed almost exclusively in testis, SSX mRNA is expressed in various human tumors, defining SSX as a cancer/testis antigen. We have now cloned the mouse ortholog of SSX. Mouse SSX genes can be divided into Ssxa and Ssxb subfamilies based on sequence homology. Ssxa has only one member, whereas 12 Ssxb genes, Ssxb1 to Ssxb12, were identified by cDNA cloning from mouse testis and mouse tumors. Both Ssxa and Ssxb are located on chromosome X and show tissue-restricted mRNA expression to testis among normal tissues. All putative human and mouse SSX proteins share conserved KRAB and SSX-RD domains. Mouse tumors were found to express some, but not all, Ssxb genes, similar to the SSX activation in human tumors.

authors

  • Chen, Yao-Tseng
  • Alpen, Birgit
  • Ono, Toshiro
  • Gure, Ali O
  • Scanlan, Matthew A
  • Biggs, William H
  • Arden, Karen
  • Nakayama, Eiichi
  • Old, Lloyd J

publication date

  • December 1, 2003

Research

keywords

  • Gene Expression
  • Multigene Family
  • Neoplasm Proteins
  • RNA, Messenger
  • Repressor Proteins
  • Testis
  • X Chromosome

Identity

Scopus Document Identifier

  • 0242678277

Digital Object Identifier (DOI)

  • 10.1016/s0888-7543(03)00183-6

PubMed ID

  • 14611804

Additional Document Info

volume

  • 82

issue

  • 6