BRCA2-RAD51-DSS1 interplay examined from a microbial perspective. Academic Article uri icon

Overview

abstract

  • The tumor suppressor BRCA2 plays an essential role in the repair of double-strand DNA breaks by regulating the action of the RAD51 recombinase. The activity of BRCA2 is in turn governed by DSS1, a small acidic protein that appears to function as a necessary cofactor. A model fungal system that reproduces the BRCA2-RAD51 interaction offers the opportunity to understand the mechanism of DSS1 activation at the molecular level.

publication date

  • March 1, 2004

Research

keywords

  • BRCA2 Protein
  • DNA-Binding Proteins
  • Infections

Identity

Scopus Document Identifier

  • 15044346358

Digital Object Identifier (DOI)

  • 10.4161/cc.3.3.701

PubMed ID

  • 14726651

Additional Document Info

volume

  • 3

issue

  • 3