Combined intravenous methotrexate and cyclophosphamide for refractory childhood lupus nephritis. Academic Article uri icon

Overview

abstract

  • OBJECTIVE: To evaluate the efficacy and safety of combining monthly intravenous methotrexate (IV MTX) with monthly IV cyclophosphamide (CYTX; given on the same day) for the treatment of children who develop recurrent diffuse proliferative glomerulonephritis secondary to systemic lupus erythematosus during or after the standard 3 year course of IV CYTX. METHODS: Five children were treated with nine monthly doses of IV CYTX (750-1000 mg/m(2)/month) and IV MTX (50-300 mg/m(2)/month) given on the same day. Their clinical and laboratory measurements were collected every other week throughout the nine months. RESULTS: All children improved dramatically. SLEDAI scores decreased from an average of 13.8 to 4.4, mean (SD) serum creatinine level fell from 100 (60) to 80 (40) micro mol/l, and serum albumin rose from 28 (11) g/l to 41 (6) g/l, while the mean (SD) C3 level increased from 0.5 (0.1) g/l to 0.9 (0.4) g/l. Clinical improvement persisted after 4 years' follow up despite discontinuing MTX and CYTX after 9 months. The average daily dose of corticosteroids has been reduced from 27.6 mg/day at the start of treatment to 12.5 mg/day at follow up. CONCLUSION: Combined IV MTX and IV CYTX treatment effectively controls recurrent or refractory lupus nephritis in children with significant disease activity after treatment with IV CYTX alone.

publication date

  • March 1, 2004

Research

keywords

  • Cyclophosphamide
  • Immunosuppressive Agents
  • Lupus Nephritis
  • Methotrexate

Identity

PubMed Central ID

  • PMC1754922

Scopus Document Identifier

  • 1342343990

Digital Object Identifier (DOI)

  • 10.1136/ard.2003.008342

PubMed ID

  • 14962970

Additional Document Info

volume

  • 63

issue

  • 3