Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens. Academic Article uri icon

Overview

abstract

  • Regulatory T (T(R)) cells maintain tolerance to self-antigens and control immune responses to alloantigens after organ transplantation. Here, we show that CD4(+) CD25(+) human T(R) cells suppress virus-specific T-cell responses. Depletion of T(R) cells from peripheral blood mononuclear cells enhances T-cell responses to cytomegalovirus and human immunodeficiency virus antigens. We propose that chronic viral infections lead to induction of suppressive T(R) cells that inhibit the antiviral immune response.

publication date

  • March 1, 2004

Research

keywords

  • Antigens, Viral
  • CD4-Positive T-Lymphocytes
  • Cytomegalovirus
  • HIV
  • Receptors, Interleukin-2

Identity

PubMed Central ID

  • PMC369239

Scopus Document Identifier

  • 10744227590

Digital Object Identifier (DOI)

  • 10.1128/jvi.78.5.2454-2459.2004

PubMed ID

  • 14963140

Additional Document Info

volume

  • 78

issue

  • 5