The effect of phosphoramidon on inflammation-mediated preterm delivery in a mouse model. Academic Article uri icon

Overview

abstract

  • OBJECTIVE: Several metallopeptidases have been implicated in both term and preterm parturition. We hypothesize that endotoxin-induced preterm delivery can be prevented by the administration of a metallopeptidase inhibitor. STUDY DESIGN: We used an animal model of endotoxin-induced preterm delivery in timed pregnancy C57Bl/6 mice. Test animals received lipopolysaccharide followed by phosphoramidon, either every 1.5 or every 3 hours. Control mice received lipopolysaccharide followed by buffer injections at the same intervals. The primary outcome was a preterm delivery rate. RESULTS: The rate of preterm delivery for the control animals was 88.0% compared with the treatment groups of 45.5% for the mice that received phosphoramidon every 3 hours and 30.8% for the group that received it every 1.5 hours (P<.01). CONCLUSION: The administration of a metallopeptidase inhibitor resulted in a decreased rate of preterm delivery in this animal model.

publication date

  • February 1, 2004

Research

keywords

  • Glycopeptides
  • Metalloendopeptidases
  • Obstetric Labor, Premature
  • Protease Inhibitors

Identity

Scopus Document Identifier

  • 1342281750

Digital Object Identifier (DOI)

  • 10.1016/j.ajog.2003.08.021

PubMed ID

  • 14981401

Additional Document Info

volume

  • 190

issue

  • 2