Mutant genes responsible for Parkinson's disease. Review uri icon

Overview

abstract

  • Recent progress has documented the presence of at least 10 disease-related genes or loci linked to Parkinson's disease. Analysis of the genotypes and phenotypes of these mutant genes has revealed a broad spectrum of clinical and pathological presentations, many of which share a common feature of alteration in the ubiquitin proteasome system. Further understanding of the pathogenesis of these inherited cases of Parkinson's disease and development of transgenic animal models bearing these mutations should provide novel insight into the causes of nigral cell death and meaningful strategies for future therapy.

publication date

  • February 1, 2004

Research

keywords

  • Mutation
  • Parkinson Disease

Identity

Scopus Document Identifier

  • 0742306066

Digital Object Identifier (DOI)

  • 10.1016/j.coph.2003.09.005

PubMed ID

  • 15018843

Additional Document Info

volume

  • 4

issue

  • 1